Publications

 

Manuscripts

Monteran L, Ershaid E, Sabah I, Fahoum I, Zait Y, Shani O, Cohen N, Eldar-Boock A, Satchi-Fainaro R, and Erez N. Bone metastasis is associated with acquisition of mesenchymal phenotype and immune suppression in a model of spontaneous breast cancer metastasis. Sci Rep. 2020 Aug 14;10(1):13838. PDF

Shani O, Raz Y, Monteran L, Scharff Y, Levi-Galibov O, Megides O, Shacham H, Cohen N, Silverbush D, Avivi C, Sharan R, Madi A, Scherz-Shouval R, Barschak I, Tsarfaty I, and Erez N. Evolution of  fibroblasts in the lung metastatic microenvironment is driven by stage-specific transcriptional plasticity. 2021. eLife. PDF

Ershaid N, Sharon Y, Doron H, Raz Y, Shani O, Cohen N, Monteran L, Leider-Trejo L, Ben-Shmuel A, Yassin M, Gerlic M, Ben-Baruch A, Pasmanik-Chor M, Apte R and Erez N. NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis. Nat Commun. 2019;10(1):4375. PDF

Doron H, Amer M, Ershaid N, Blazquez R, Shani O, Gener Lahav T, Cohen N, Adler O, Hakim Z, Pozzi S, Scomparin A, Cohen J, Yassin M, Monteran L, Grossman R, Tsarfaty G, Luxenburg C, Satchi-Fainaro R, Pukrop T and Erez N. Inflammatory Activation of Astrocytes Facilitates Melanoma Brain Tropism via the CXCL10-CXCR3 Signaling Axis. Cell Reports. 2019;28(7):1785-1798.e6. PDF

Gener Lahav T, Adler O, Zait Y, Shani O, Amer M, Doron H, Abramovitz L, Yofe I, Cohen N and Erez N. Melanoma-derived extracellular vesicles instigate proinflammatory signaling in the metastatic microenvironment. IJC. 2019;145(9):2521-2534. PDF

Cohen N and Erez N. FACS Analysis of Col1α Protein Levels in Primary Fibroblasts. Methods Mol Biol. 2019;1944:221-228. PDF

Raz Y, Cohen N, Shani O, Bell RE, Novitskiy SV, Abramovitz L, Levy C, Milyavsky  M, Leider-Trejo  L, Moses HL, Grisaru D and Erez N. Bone marrow-derived fibroblasts are a functionally distinct stromal cell population in breast cancer. Journal of Experimental Medicine. 2018;215(12):3075-3093. PDF 

Ben Baruch B, Blacher E, Mantsur E, Schwartz H, Vaknine H, Erez N, and Stein R. Stromal CD38 regulates outgrowth of primary melanoma and generation of spontaneous metastasis. Oncotarget, 9(61), 31797-31811. PDF

Blau R, Epshtein Y, Pisarevsky E, Tiram G, Israeli Dangoor S, Yeini E, Krivitsky A, Eldar-Boock A, Ben-Shushan D, Gibori H, Scomparin A, Green O, Ben-Nun Y, Merquiol E, Doron H, Blum G, Erez N, Grossman R, Ram Z, Shabat D and Satchi-Fainaro R. Image-guided surgery using near-infrared Turn-ON fluorescent nanoprobes for precise detection of tumor margins. Theranostics, 8(13), 3437-3460. PDF

Herkel J, Schrader J, Erez N, Lohse A and Cohen IR. Activation of the Akt-CREB signaling axis by a proline-rich heptapeptide confers resistance to stress-induced cell-death and inflammation. Immunology. 2017 Apr 17. PDF

Klein A, Sagi-Assif O, Meshel T, Telerman A, Izraely S, Ben-Menachem S, Bayry J, Marzese D, Ohe S, Hoon D, Erez N and Witz I. CCR4 is a determinant of melanoma brain metastasis. Oncotarget. 2017 Mar 10. PDF

Cohen N, Shani O, Raz Y, Sharon Y, Hoffman D, Abramovitz L and Erez N. Fibroblasts drive an immunosuppressive and growth-promoting microenvironment in breast cancer via secretion of Chitinase 3-like 1. Oncogene. 2017 Apr 3. PDF 

Dror S, Sander L, Schwartz H, Sheinboim D, Barzilai A, Dishon Y, Apcher S, Golan T, Greenberger S, Barshack I, Malcov H, Zilberberg A, Levin L, Nessling M, Friedmann Y, Igras V, Barzilay O, Vaknine H, Brenner R, Zinger A, Schroeder A, Gonen P, Khaled M, Erez N, Hoheisel JD and Levy C. Melanoma miRNA trafficking triggers tumor primary niche formation. Nature Cell Biology. 2016 Sep;18(9):1006-17. PDF 

Schwartz H, Blacher E, Amer M, Livneh N, Abramovitz L, Klein A, Ben-Shushan D, Soffer S, Blazquez R, Barrantes-Freer A, Müller M, Müller-Decker K, Stein R, Tsarfaty G, Satchi-Fainaro R, Umansky V, Pukrop T and Erez N. Incipient melanoma brain metastases instigate astrogliosis and neuroinflammation. Cancer Res. 2016 Aug 1;76(15):4359-71. PDF

Rietkötter E, Bleckmann A, Bayerlowa M, Menck K, Chuang H-N, Wenske B, Schwartz H, Erez N, Binder C, Hanisch U-K, and Pukrop T. Anti-CSF-1 treatment is effective to prevent carcinoma invasion induced by monocyte-derived cells (MCs) but scarcely by microglia. Oncotarget. 2015 Jun 20;6(17):15482-93. PDF

Klein A, Schwartz H, Sagi-Assif O, Meshel T, Izraely S, Ben Menachem S, Bengaiev R, Ben-shmuel A,  Nahmias C, Couraud PO, Witz IP, Erez N. Astrocytes facilitate melanoma brain metastasis via secretion of IL-23. J Pathol. 2015 May;236(1):116-27. PDF

Sharon Y, Raz Y, Cohen N, Ben-Shmuel A, Schwartz H, Geiger T and Erez N. Tumor-derived Osteopontin reprograms normal mammary fibroblasts to promote inflammation and tumor growth in breast cancer. Cancer Res. 2015 Mar 15;75(6):963-73. PDF

Erez N, Glanz S, Raz Y, Avivi C, and Barshack I. Cancer associated fibroblasts express pro-inflammatory factors in human breast and ovarian tumors. Biochem Biophys Res Commun. 2013 Aug 2;437(3):397-402. PDF

Sharon Y, Alon L, Glanz S, Servais S and Erez N. Isolation of Normal and Cancer-Associated Fibroblasts from fresh tissues by Fluorescence Activated Cell Sorting (FACS). J Vis Exp. 2013 Jan 14;(71):e4425 PDF

Klein A, Sagi-Assif O, Izraely S, Meshel T, Pasmanik-Chor M, Nahmias C, Couraud PO, Erez N, Hoon DSB and Witz IP. The metastatic microenvironment. Brain-derived soluble factors alter the malignancy phenotype of cutaneous and brain- metastasizing melanoma cells. Int J Cancer. 2012 Dec 1;131(11):2509-18 PDF

Shani O, Vorobyov T, Monteran L, Lavie D, Cohen N, Raz Y, Tsarfaty G, Avivi C, Barshack I and Erez N. Fibroblast-derived IL-33 facilitates breast cancer metastasis by modifying the immune microenvironment and driving type-2 immunity. Cancer Res. 2020 Oct 6:canres.2116.2020. PDF

Erez N, Truitt M, Olson P, and Hanahan D. Cancer Associated Fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kB-dependent manner. Cancer Cell. 2010 Feb 17;17(2):135-47.(Featured in: Cancer Cell 2010, February; 17 (2):  111-112). PDF

Pahler JC, Tazzyman S, Erez N, Chen Y, Murdoch C, Nozawa H, Lewis C, Hanahan D.  Plasticity in tumor-promoting inflammation: impairment of macrophage recruitment evokes a compensatory neutrophil response. Neoplasia. 2008 Apr;10(4):329-40. PDF

Efrati S, Berman S, Goldfinger N, Erez N, Averbukh Z, Golik A, Rotter V, and Weissgarten J. Enhanced angiotensin II production by renal mesangium is responsible for apoptosis/proliferation of endothelial and epithelial cells in a model of malignant hypertension. J Hypertens. 2007 May;25(5):1041-52 PDF

Milyavsky M, Tabach Y, Shats I, Erez N, Cohen Y, Tang X, Kalis M, Kogan I, Buganim Y, Goldfinger N, Ginsberg D, Harris CC, Domany E, and Rotter V. Transcriptional programs following genetic alterations in p53, INK4A, and H-Ras genes along defined stages of malignant transformation. Cancer Res. 2005 Jun 1;65(11):4530-43. PDF

Herkel J, Kam N, Erez N, Mimran A, Heifetz A, Eisenstein M, Rotter V and Cohen IR. Monoclonal antibody to a DNA-binding domain of p53 mimics charge structure of DNA: anti-idiotypes to the anti-p53 antibody are anti-DNA. Eur J Immunol. 2004 Dec;34(12):3623-32. PDF

Shats I, Milyavsky M, Tang X, Stambolsky P, Erez N, Brosh R, Kogan I, Braunstein I, Tzukerman M, Ginsberg D and Rotter V. p53-dependent downregulation of telomerase is mediated by p21/waf1. J Biol Chem. 2004 Dec 3;279(49):50976-85. PDF

Tang X, Milyavsky M, Shats I, Erez N, Goldfinger N and Rotter V. Activated p53 suppresses the histone methyltransferase EZH2 gene. Oncogene. 2004 Jul 29;23(34):5759-69. PDF

Erez N, Stambolsky P, Shats I, Milyavsky M, Kachko T and Rotter V. Hypoxia-dependent regulation of PHD1: Cloning and Characterization of the human PHD1/EGLN2 gene promoter. FEBS Lett. 2004 Jun 4;567(2-3):311-5. PDF

Erez N, Milyavsky M, Eilam R, Shats I, Goldfinger N, and Rotter V. Expression of prolyl-hydroxylase-1 (PHD1/EGLN2) suppresses hypoxia inducible factor-1alpha activation and inhibits tumor growth. Cancer Res. 2003 Dec 15;63(24):8777-83. PDF

Milyavsky M, Shats I, Erez N, Tang X, Senderovich S, Meerson A, Tabach Y, Goldfinger N, Ginsberg D, Harris CC and Rotter V. Prolonged culture of telomerase-immortalized human fibroblasts leads to a premalignant phenotype. Cancer Res. 2003 Nov 1;63(21):7147-57. PDF

Shats I, Milyavsky M, Erez N and Rotter V. The murine telomerase catalytic subunit shares the PAb-240 mutant specific epitope of the p53 protein. FEBS Lett. 2003 Jul 10;546(2-3):321-4. PDF

Erez N, Milyavsky M, Goldfinger N, Peles E, Gudkov AV and Rotter V. Falkor, A Novel Cell Growth Regulator Isolated by a Functional Genetic Screen. Oncogene 2002. Oct 3;21(44):6713-21. PDF

Offer I, Erez N, Zurer I, Tang X, Milyavsky M, Goldfinger N and Rotter V. The onset of p53-dependent DNA repair or apoptosis is dependent on DNA damaging levels. Carcinogenesis. 2002 23 (6):1025-1032 PDF

Milyavsky M, Mimran A, Senderovich S, Zurer I, Erez N, Shats I, Goldfinger N, Cohen I and Rotter V. Activation of p53 protein by telomeric (TTAGGG)(n) repeats. Nucleic Acids Res. 2001 Dec 15;29(24):5207-15. PDF

Herkel J, Mimran A, Erez N, Kam N, Lohse AW, Märker-Hermann E, Rotter V and Cohen IR. Autoimmunity to the p53 Protein is a Feature of Systemic Lupus Erythematosus (SLE) Related to Anti-DNA Antibodies. J Autoimmunity. 2001 17, pp. 63-69. PDF

Offer H, Milyavsky M, Erez N, Matas D, Zurer I, Harris CH and Rotter V. Structural and functional involvement of p53 in BER in vitro and in vivo. Oncogene. 2001 (20): 581-589. PDF

Herkel J, Erez-Alon N, Wolkowicz R, Harmelin A, Ruiz PJ, Rotter V and Cohen IR. Systemic lupus erythematosus in mice, spontaneous and induced, is associated with autoimmunity to the C-terminus domain of p53 that recognizes damaged DNA. Eur J Immunol. 2000 Apr;30(4):977-984. PDF

Erez-Alon N, Herkel J, Wolkowicz R, Ruiz PJ, Waisman A, Rotter V and Cohen IR. Immunity to p53 induced by an idiotypic network of anti-p53-antibodie: Generation of sequence-specific anti-DNA antibodies and protection from tumor metastasis. Cancer Res. 1998. 58, 5447-5452. PDF

Ruiz PJ, Wolkowicz R, Waisman A, Hirschberg DL, Carmi P, Erez N, Garren H, Herkel J, Karpuj M, Steinman L, Rotter V and Cohen IR. Idiotypic immunization induces immunity to mutated p53 and tumor rejection. Nat. Med. 1998 4: 710-712. PDF

Reviews

 

Monteran L and Erez N. The Dark Side of Fibroblasts: Cancer-Associated Fibroblasts as Mediators of Immunosuppression in the Tumor Microenvironment. Front Immunol. 2019 Aug 2. PDF

Hila Doron, Tobias Pukrop and Neta Erez. A Blazing Landscape: Neuroinflammation Shapes Brain Metastasis. Cancer Res. January 24 2019. PDF

Erez N. Fibroblasts form a hospitable metastatic niche in the liver. Nat Cell Biol. 2016 Apr 27. PDF

Erez N. Cancer: Opening LOX to metastasis. Nature. 2015 May 27. PDF

Erez N. Cancer: Angiogenic Awakening. Nature. 2013 Jul 24. PDF

Raz Y and Erez N. An inflammatory vicious cycle: fibroblasts and immune cell recruitment in cancer. Exp Cell Res. 2013 Apr 5. PDF

Servais C and Erez N. From Sentinel Cells to Inflammatory Culprits: Cancer-Associated Fibroblasts in Tumor-related Inflammation. J Pathol. 2013 Jan. PDF

Erez N and Coussens LM. Leukocytes as Paracrine Regulators of Metastasis and Determinants of Organ-Specific Colonization. Int J Cancer. 2011 Jun 1;128(11):2536-44. PDF