The main goal of our laboratory is to uncover stromal pathways that contribute to tumor progression and metastasis
Extensive research has led to the understanding that tumors are more than just cancer cells: stromal cells in the tumor microenvironment play a crucial role in all stages of tumor initiation and progression, and metastatic relapse. Cancer research in recent years is no longer focused only on the pathways inside tumor cells, but rather on understanding the biology of tumors as multi-cellular organs.
The major cause of cancer mortality is metastasis to distant organs. Currently, metastatic cancers are mostly incurable and available therapies can only prolong life to a limited extent. Therefore, uncovering the mechanisms that facilitate metastasis is an urgent and unmet clinical need. There is a growing understanding that the metastatic microenvironment is crucial in enabling the growth of disseminated cancer cells. Nevertheless, changes in the metastatic microenvironment that enable the growth of metastasizing tumor cells are poorly characterized, and our research is focused on elucidating them.
We combine state-of-the-art transgenic mouse models with gene expression profiling, intra-vital imaging, ex-vivo models and pre-clinical functional approaches to reveal the molecular events at the metastatic microenvironment that create a hospitable niche for metastatic growth.
Our main focus is on studying the role of tumor-promoting inflammation and immune suppression in breast cancer and melanoma metastasis to lung, brain and bone. Expanding our understanding of the early stages of metastatic growth is an essential prerequisite for the discovery of novel target molecules for the design of targeted therapeutics that may prevent, rather than try to cure, metastatic disease.
Characterizing the dynamic co-evolution of fibroblasts and immune cells during breast cancer metastasis.
Uncovering the formation of the pre-metastatic niche in lungs and bones.
Elucidating the reciprocal interactions between cancer-associated fibroblasts and immune cells in the tumor microenvironment.
Characterizing the role of astrocytes and neuroinflammation in melanoma brain metastasis.
Characterizing exosome-mediated signaling in melanoma metastasis to lungs and brain.
Establishing novel models of breast cancer and ovarian cancer metastasis.